Scholar Rock is a clinical-stage biopharmaceutical company creating a robust pipeline of therapeutics with the potential to transform the lives of patients suffering from serious diseases, including neuromuscular disorders, cancer, and fibrosis. Our proprietary platform is rooted in our structural biology insights into the activation of latent growth factor precursors and drives the discovery and development of monoclonal antibodies that locally and selectively target these signaling proteins at the cellular level. By exploiting structural differences in the precursor, or latent forms of growth factors, Scholar Rock intends to avoid the historical dose-limiting safety challenges associated with inhibiting the mature form of growth factors for therapeutic effect.
Our first investigational product candidate, apitegromab (SRK-015), is a selective inhibitor of the activation of latent myostatin. We announced positive 12-month top-line data from the TOPAZ trial in April 2021, demonstrating that apitegromab has the potential to improve motor function in patients with Type 2 and Type 3 spinal muscular atrophy (SMA). We anticipate initiating a Phase 3 registrational trial by the end of 2021 and are moving steadfast towards our aim of bringing this potential first muscle-directed therapy to patients with SMA
Our second investigational product candidate, SRK-181, is a selective inhibitor of latent TGFβ1 activation being developed to overcome primary resistance to checkpoint inhibitor therapies (CPIs), such as anti-PD-1 or anti-PD-L1 antibodies. Although CPIs have transformed the cancer treatment landscape, only approximately 20% of patients respond to treatment. We believe SRK-181 has the potential to meaningfully increase the number of patients who can benefit from CPIs. We are evaluating SRK-181 in the ongoing DRAGON Phase 1 proof-of-concept trial (NCT04291079) evaluating patients with locally advanced or metastatic solid tumors. We anticipate initial clinical response and safety data from Part A (dose escalation) portion of the trial by the end of 2021.
We continue to progress our scientific platform and preclinical programs as we apply our structural insights and protein science and antibody expertise to discover antibodies with differentiated therapeutic profiles and develop high-impact medicines for patients suffering from serious diseases.
Summary of Position:
We’re looking for a proactive Lab Manager who can help Scholar Rock anticipate our lab needs as we grow. The Lab Manager is responsible for managing the daily activities of the lab support team, the equipment maintenance program, the critical alarm system, anticipating and identifying opportunities to further support the science staff and providing daily hands-on support in the labs. This position requires daily interaction with the scientific and lab support teams. Serves as a chemical gatekeeper in the ordering process and further supports the EHS team in various inspectional activities. The Lab Manager is required to maintain a professional working relationship with various vendors and contractors, as well as the ability to respond as needed to all related requests, both routine and urgent from the scientific staff.
Manage the Computerized Maintenance Management System for lab equipment
Manage new equipment contracts and PM contracts
Support new equipment purchases
Review and approve calibration and PM documentation
Maintain the lab equipment master schedule
Schedule maintenance vendors for planned/unplanned maintenance events
Author/revise maintenance and calibration SOPs
Ability to perform routine preventive and corrective maintenance tasks on laboratory equipment
Assist staff / management in technical aspects of instrumentation (i.e. specifications, test points)
Manage daily activities of the Lab Support team and oversee day to day laboratory operations
Coordinate with the research teams for the allocation of lab space and equipment
Implement process improvements in the lab support functional areas
Package and ship materials for science staff
Manage the off-site storage program
Manage the critical alarm system and respond off hours to alarm events when required
Work with finance and procurement to perform documentation receipt of all incoming materials
Communicates with internal customers and our vendors regarding back orders, incorrect orders, RMA’s
Manage stock rooms and inventory systems
Organize and conduct regularly scheduled meetings with team members and science staff
DOT and IATA certification
A minimum of 3 years of experience working in Lab Support for the biotechnology sector
Ability to pick up 75 pounds
Ability to work off a four (4) foot high step ladder
Excellent verbal and written communication skills
Excellent organization, time management skills
Effective interpersonal skills
Ability to be proactive and work with limited supervision
Proficiency in MS Office with the ability to generate presentations, spreadsheets, reports
Scholar Rock is an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.