Calico is a research and development company whose mission is to harness advanced technologies to increase our understanding of the biology that controls lifespan and healthspan, and to devise interventions that enable people to lead longer and healthier lives. Executing on this mission will require an unprecedented level of interdisciplinary effort and a long-term focus for which funding is already in place.
Calico is seeking a computational biologist to join a team of scientists investigating aging and age-related diseases using genetics and functional genomics in humans and a diversity of model systems.
Genomics offers rich, informative profiles of organism state during aging. We collect these data to build causal models for organism state, that reveal the critical underlying cellular processes and more readily highlight promising intervention points. The ideal candidate is passionate about working to better understand how genomes work and their role in propagating the harmful changes that occur during aging.
Predictive modeling with cutting edge machine learning tools are at the core of this work, exemplified by recent publications modeling regulatory activity as a function of DNA sequence using deep learning.