Dyno Therapeutics is reshaping the gene therapy landscape through AI-powered vectors. Through the application of our transformative technologies and strategic partnerships with leaders in gene therapy, we believe a future with life changing gene therapies for millions of people is within reach.
Our team includes world-class molecular and synthetic biologists, protein engineers and gene therapy scientists working alongside software engineers, data scientists, and machine learning experts.Dyno was named Startup of the Year in 2020 by Xconomy!
Senior Research Associate - NGS; AAV Engineering. Under the guidance of senior researchers, you will support a number of stages in the Dyno pipeline via NGS library preparation, quantification, QC analysis, and sequencing of NGS libraries at Dyno and with external service providers. Crucial to this role is careful coordination of samples and communication between multiple fast-paced teams, along with a strong sense of organization, attention to detail, consistency, and rigor.
How You Will Contribute
As a member of the scientific team, you will work with fellow Dyno scientists to prepare NGS libraries, coordinate NGS across Dyno’s platform and analyze the quality of NGS library preparations while also developing, and optimizing detailed protocols as the need arises. You will collaborate with scientists and computational biologists – learning from and contributing to a diverse set of projects. You will be responsible for understanding project goals and for developing creative solutions to ensure their success.
Prepare NGS libraries from DNA and RNA samples.
Quantify, QC, and prepare library samples to load on NGS instruments at Dyno or with CROs.
Establish and maintain a sample submission and tracking system to coordinate NGS activities across Platform teams.
Coordinate sample and data handling between wet-lab and data science teams.
Preparation of reports and presentation of results in team and company-wide meetings
Assist in lab organization, including ordering supplies and restocking
Follow lab protocols and safety rules
Who you are
Thoughtful & detail oriented
Work with a sense of urgency
Appreciation for opportunities at the intersections of data science and biology
BA or MA in biology, biochemistry, biomedical engineering, or related fields
Minimum 2+ years full-time wet lab experience, 3+ years full-time professional laboratory experience preferred
Highly skilled in the following technical skills:
NGS library preparation from DNA and RNA samples, including amplicon sequencing, RNA-seq, or custom library preparation methods for Illumina
Library quantification and QC analysis using a variety of methods including Bioanalyzer, fluorescence quantification, and qPCR
Custom sample indexing and pooling for multiple applications
Ability to conduct advanced protocols precisely and consistently
Highly organized and detail oriented
Ability to maintain organized documentation of lab work and results
Previous experience loading and operating Illumina sequencing instruments and using Illumina Sequencing Analysis Viewer (SAV) software
Previous experience implementing a sample submission and tracking systems is a plus
Previous experience with sequence analysis software, such as Benchling, bcl2fastq, and other aligners is a plus
We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.