Dyno Therapeutics is reshaping the gene therapy landscape through AI-powered vectors. Through the application of our transformative technologies and strategic partnerships with leaders in gene therapy, we believe a future with life changing gene therapies for millions of people is within reach.
Our team includes world-class molecular and synthetic biologists, protein engineers and gene therapy scientists working alongside software engineers, data scientists, and machine learning experts to transform the landscape of available gene therapy capsids. Dyno was named Startup of the Year in 2020 by Xconomy!
Sr. Scientist - In vitro Assay Development; AAV Engineering. We are seeking a focused, creative and enthusiastic scientist to join the In Vitro Assays team, in the Applied Biology group. Working in a small team setting, you will play a central role in advancing Dyno’s discovery pipeline through design and implementation of new functional assays. Your role will be to build and apply methods for measuring properties of synthetic AAV capsids in vitro to inform discovery of novel capsids with improved biological properties. Successfully meeting these challenges will require not only a broad range of molecular biology skills, independent thinking, and an aptitude for troubleshooting, but also the drive to develop creative new technologies as opportunities arise. The ideal candidate relishes interdisciplinary collaboration between the wet lab and the data science teams.
How You Will Contribute
As a member of the scientific team, you will work with fellow Dyno scientists in Applied Biology and Data Science to develop new technological directions and bring them from concept into the platform workflow. You will develop new cell-based and cell-free methods to evaluate the function of synthetic AAV capsids in vitro using next-generation sequencing to measure capsid performance. In this role you will be able to exercise your scientific creativity and aptitude for optimization and troubleshooting of diverse methods across biochemistry, molecular biology and cell biology. You will also have opportunities to mentor junior personnel and develop your project management and collaboration skills.
Design and test novel high-throughput assays to measure AAV capsid functions, such as in vitro transduction and evasion of neutralizing antibodies
Transition new high-throughput assays from proof-of-concept into standardized workflows
Oversee AAV library construction and production when relevant to methodological testing
Maintain up-to-date expertise in the field across technologies relevant to the role
Independently advance projects through collaboration with a diverse team of wet-lab scientists, protein engineers, and computational scientists
Interpret data and present work at internal lab meetings
Who you are
Thoughtful and detail oriented
Works with a sense of urgency
Enthusiastic for opportunities at the intersections of data science and biology
PhD in molecular biology, virology, immunology, or a related discipline
5+ years hands-on wet lab experience
2+ years relevant industry experience
Strong track record in developing novel and robust assays
Background in virology (AAV, parvoviruses) or immunology research (antiviral immunity)
Hands-on experience in DNA/RNA analysis and related methods (qPCR, RT-qPCR, etc.)
Strong collaborative, organizational, and presentation skills
Ability to independently advance projects to completion
Ability to document, maintain, and share an organized account of lab work and results
3+ years post-PhD experience
Experience with next-generation sequencing methods and library preparation
Experience with microscopy, flow cytometry and cell sorting, and histology
Experience with protein analysis methods – SDS-PAGE, Bradford, Western blots, ELISA or HPLC/FPLC
We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.