Scholar Rock is a clinical-stage biopharmaceutical company focused on the discovery and development of innovative medicines for the treatment of serious diseases in which signaling by protein growth factors plays a fundamental role.
Our most advanced investigational product candidate, apitegromab (SRK-015), a selective inhibitor of the activation of the growth factor myostatin in skeletal muscle, is in development for the treatment of spinal muscular atrophy, or SMA. Following positive results from the TOPAZ Phase 2 trial in patients with Type 2 and Type 3 SMA, we are planning to advance to a Phase 3 trial by year-end. In addition, we are conducting our DRAGON Phase 1 proof-of-concept trial for SRK-181, a selective inhibitor of latent TGFβ1 activation, in patients with locally advanced and metastatic solid tumors.
By combining our deep structural insights with antibody drug discovery, Scholar Rock is creating a pipeline of novel product candidates with the potential to transform the lives of patients suffering from a wide range of serious diseases, including neuromuscular disorders, cancer, and fibrosis.
Summary of Position:
At Scholar Rock, our mission is to help patients with serious illnesses through innovative thinking, cutting edge science, and a passion for discovering and developing novel therapeutics. We are seeking an outstanding Sr./ Scientist to join our Discovery Biology team. This individual will have broad responsibilities to lead new research projects and to support research needs in our rapidly growing R&D organization. The successful candidate will make a significant impact in advancing our therapeutic candidates across multiple disease areas with high unmet need, including neuromuscular diseases and metabolic dysfunctions. The candidate will collaborate closely with internal research teams covering protein sciences, antibody discovery, and preclinical development to identify and validate therapeutic targets.
Contribute to conceptualizing, proposing, and executing plans to identify and validate new targets in the areas of metabolic dysfunctions and neuromuscular diseases.
Collaborate in cross-functional discovery teams to move antibody candidates through the discovery process towards development candidate nomination and support current teams in these areas.
Independently develop, validate, execute, and analyze in vitro and ex vivo screening assays and mechanistic studies.
Lead characterization of antibody drug candidates in preclinical pharmacology models.
Support our culture of scientific excellence and cross-functional collaboration.
Strengthen our internal capabilities and build external collaborations in biology and pharmacology related to our programs, particularly in the areas of muscle biology and metabolism.
Ensure each activity is effectively prioritized with appropriate use of internal resources, CROs, and academic / industrial collaborations to deliver optimal results.
Maintain detailed records of experimental protocols and data in laboratory notebooks in accordance with company policy.
Analyze, interpret and present experimental results at internal and external meetings.
PhD in cell biology, pharmacology, molecular biology or related field with a minimum of 3+ years of hands-on industry experience. BS/MS with a minimum of 5+ years of industry experience in similar roles will also be considered.
The preferred candidate will possess requisite skills, first-hand experience, and a deep understanding of molecular and cell biology methods covering a broad range of research techniques. Experience with antibody therapeutics is desired.
Familiarity with disease biology and pharmacology models in the areas of neuromuscular diseases and/or metabolic dysfunctions is required. Experience managing external CROs is a plus.
Experience with mammalian cell culture is required. Experience with high or medium throughput screening of therapeutic candidates using cell-based assays is preferred.
Strong collaboration skills, with an ability to influence multiple stakeholders and build mutual trust, respect, and cooperation among team members.
Ability to balance resources and priorities to concurrently deliver on multiple objectives under aggressive timelines.
Excellent written and oral communication skills. Ability to articulate solutions to challenging research and translational development questions across diverse functional areas and backgrounds.
Self-motivated and comfortable operating independently and within teams.
Scholar Rock is an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.