Denali Therapeutics is dedicated to developing breakthrough therapies for neurodegenerative diseases through the application of a deep understanding of degeneration biology and principles of translational medicine.
We are seeking an outstanding Sr Scientist, Analytical Biochemistry, to join our Biotherapeutics Discovery / Analytical and Developability Team in South San Francisco.
Implement a diverse set of methods to assess the developability of lead panel molecules. The methods include calorimetric assays, spectroscopy, light scattering, chromatography, electrophoresis, and other physiochemical techniques
Implement real-time and accelerated stability studies of lead candidate(s) in the lead optimization and selection stages
Identify and Develop high throughput assays towards minimizing material utilized while maximizing the data for developability as needed
Collaborate with other scientists to conduct stage-appropriate developability assessments for therapeutic candidate development
Assess biophysical and analytical properties of molecules entering cell line and process development for enabling purification and formulation development
Coordinate internal activities and studies at contract research and manufacturing organizations supporting generation of analytical data package for IND filing
Master’s degree with at least 6-8 years of industry experience or a Ph.D. with 3-5 years of post-doctoral or industry experience
Hands-on experience with biophysical and analytical characterization methods including HPLC, cIEF, DSF/DSC, spectroscopy and light scattering
Experience in conducting formulation and stability studies preferred
Experience in protein characterization and mass spectrometry preferred
Good understanding of protein structure, post-translational modifications, glycosylation structures, and manufacturability liabilities
Excellent oral presentation and written communication skills
Demonstrated ability to work effectively and collaboratively with other scientists on cross-functional projects teams