Denali Therapeutics is dedicated to developing breakthrough therapies for neurodegenerative diseases (e.g., Alzheimer’s, ALS, Parkinson’s Disease) through our deep commitment to degeneration biology and principles of translational medicine.
Denali Therapeutics is seeking to recruit a Biostatistician with a keen interest in clinical trials, strong programming skills, and a solid foundation in statistical theory to support pre-clinical/clinical development. This individual will provide statistical input for design, implementation, and analysis of clinical studies as well as associated biomarker development. In addition, the individual will apply a wide range of cutting-edge data analysis tools and methodology towards both publicly available as well as Denali generated data to provide novel insights and data driven hypotheses. The candidate will have the opportunity to help shape how Denali consumes and understands its data; develop an in-depth understanding of drug development in a fast-moving biotech company; identify and solve interesting and relevant problems; and contribute to improving and advancing our understanding of neurodegeneration.
Provide statistical expertise and contribute strategically to projects in all stages of drug development. This may include participation in clinical development teams as the biometrics representative.
Ensure statistical integrity of analyses and reporting deliverables, including guidance on statistical methodology, optimization of experimental design, sample size estimation, clinical development planning.
Develop and conduct exploratory analyses on both in-house and external data to gain useful insights.
Consult on programming, modeling, visualization, and statistical methodologies.
Biometrics Vendor selection and oversight.
Represent Denali Therapeutics at regulatory interactions (FDA/EMA meetings) and Advisory Committee meetings.
PhD required in Statistics, Biostatistics, or similar quantitative field with 0-2 years experience.
Pharmaceutical/Biotech industry experience preferred.
Highly independent, curious and creative, can do attitude, and embraces continuous improvement culture.
Substantial knowledge in general statistical methodology with expertise in at least one specialized area of statistics.
Strong communication and presentation skills including the ability to explain statistical concepts to a non-statistical audience.
Advanced programming skills in R.
Ability and interest to work cross functionally with basic science research and clinical colleagues
Working knowledge of a document-layout language. (Markdown, LaTeX, HTML, etc)
Working knowledge of GitHub or similar version-controlled sharing platform.