A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or "undruggable" targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA approved drugs is inhibition, but there are many other possible perturbation types whose potential remains unrealized.
Weatherwax Biotechnologies is a seed-stage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach).
Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines[2, 3, 4], and our approach will be no different.
In this unique role you will work hand-in-hand with the CEO across all aspects of our start-up, with responsibilities spanning: organization, company culture, leadership, operations, business development, legal & IP management, scientific strategy & direction, recruiting, and fundraising. You will essentially be an 'internal CEO' and will have direct ownership over many of the most important facets and growth trajectories of Weatherwax.
High Agency. Initiative, independence, and self-accountability are some of our most valued traits.
Enthusiastic. We love people who are excited about what they are doing, and are generally attempting to build a high-energy team.
Intensity and Grit. Early-stage startups are hard. Drug discovery doubly so. We are looking for candidates who have a demonstrated ability to stick with hard problems for the long haul, with a team that has your back along the way.
Prosocial. We are here to create life-saving medicines for the patients who need it most. You should be too.
Qualifications & Nice-To-Haves
PhD in a Life Sciences field, or MD, strongly preferred, but not required. You should be able to deeply understand all aspects of the scientific underpinnings of our company.
An understanding of small-molecule drug discovery and its relationship to human disease.
Excellent organizational skills.
High passion, drive, and ownership.
The ability to learn very quickly.
Everything else we can teach you :)
Strong equity incentives. You will essentially be treated as a mini-founder in terms of responsibilities and workload, and will have an equity package to match this.
Top tier medical, dental, and vision coverage + One Medical membership.
Education and health/fitness incentive programs.
Reading budget! We will buy you books 📚
Located in the MBC BioLabs Dogpatch site; an entrepreneurial hub full of the best scientists and operators the Bay Area has to offer. Our lab is a very short walk from the 22nd St Caltrain Station and a number of wonderful restaurants and cafés.
Work Hard/Play Hard. We believe time is our most valuable commodity, so we strive to create a culture that reflects this. We won’t drag you through unnecessary meetings or email you at 7 PM on a Saturday. When we're at work we're there to get things done and when we're off we're really off.
Strong Communication. We like well-written documents over PowerPoints, OKRs over vague mission statements, and weekly one-on-ones over yearly reviews.
Writing First. We have a "writing-first" culture. We believe that clarity of writing reflects clarity of thinking, and that the benefits of well-written documentation in a scientific environment are innumerable: democratization of ideation and decision making, increased reproducibility, quicker scaling and onboarding, and better company-wide alignment, to name a few.
Growth. As an early-stage startup we value scientists with an independent, can-do attitude. The more hats you can wear, the better. Our job as employers is to put you in positive-feedback loops so you can grow in the direction of your choosing.
Title and compensation commensurate with experience. Applications from candidates of diverse backgrounds, women, and members of underrepresented minority groups are particularly welcomed. We look forward to hearing from you :)