Postdoctoral Fellow, Genomics and Cell Biology - Sidrauski Lab

Calico invites creative, enthusiastic, and motivated applicants to apply for a postdoc position focused on dissecting and modeling the transcription regulatory network underlying the Integrated Stress Response (ISR). You will join our dynamic, cross-disciplinary, supportive, and collaborative team and use cutting-edge genetic and genomic techniques (e.g. single cell multiomics). You will determine the role of specific ISR regulatory nodes and seek to understand the physiological consequence of ISR dysregulation in aging and age-related diseases. The research will be tailored to meet the qualifications and interests of the postdoc, who will play a direct role in designing as well as conducting independent research.

Responsibilities:

• Design, execute, and analyze genetic and genomic experiments to probe stress response pathways in mammalian aging and disease
• Collaborate with computational and modeling teams at Calico
• Analyze and interpret data, present findings internally and externally at conferences, and prepare manuscripts for publication

Position requirements:

• PhD with experience in genetics/genomics, transcriptional networks, molecular biology, and mammalian cell culture
• Excellent communication skills for effective interaction with a collaborative network of researchers
• Competency with R and/or python-based analysis of genomic data

Calico Postdoctoral Fellowship Program:

Calico’s Postdoctoral Fellowship Program pairs recent PhD graduates with internal expertise to conduct fundamental and innovative research and investigate meaningful scientific questions aligned with our mission to understand the biology of human aging and develop interventions for age-related diseases. Postdoctoral Fellows at Calico receive mentorship and support to develop independent research programs to enable the next stage of their careers. In addition to direct mentorship from their host laboratories, Postdoctoral Fellows benefit from collaboration with diverse scientists across Calico’s Research and Technology groups and are encouraged and supported to communicate their findings through high-impact, peer-reviewed scientific journals and conferences.

Program Features:

• Fully integrated into Calico’s labs and community, Postdoctoral Fellows pursue new research directions with devoted resources for innovative and potentially high-risk research and bring new personalities, ideas, technology and perspectives to Calico.

• Calico’s program is a fixed-term educational assignment for individuals who have recently completed their PhD degrees, have had a meaningful first author paper accepted for publication, and have made important contributions to science in their area.
• While postdocs will focus on their own project(s), mutually agreed to in principle and prior to making the decision to join the mentor’s lab, the expectation is that they all contribute to furthering our understanding of aging and age-related diseases.
• Postdoc assignments are up to four years in length. It is expected that the postdoc will receive regular feedback and guidance from their mentor in addition to participating in a more formal annual review process to discuss project progress, individual performance, and career coaching.
• Our postdoc projects are expected to yield work that can be submitted for publication in a timely fashion upon completion and are intended to train people to become independent investigators in an academic or industry setting upon successful completion of the assignment.
• Calico postdocs join a community of other Postdoctoral Fellows who regularly engage with members of Calico’s scientific community, including senior leadership, through a variety of professional and career development opportunities.