Vice President, Preemptive Medicine

About Cambrian Biopharma:

Cambrian Biopharma, a multi-asset longevity biotech, is building the medicines that will redefine healthcare in the 21st century – therapeutics to lengthen healthspan, the period of life spent in good health.

By partnering with leading academic institutions and biotech entrepreneurs all over the world, we are advancing a diversified pipeline of novel therapeutics, each targeting a biological driver of aging. Our approach is to develop interventions that treat specific diseases first, then deploy them as preventative medicines to improve overall quality of life as we age.

Cambrian is a Distributed Development Company (or DisCo) which combines the advantages of a venture capital firm and a big pharmaceutical company, with the nimbleness of a biotech startup.

Cambrian’s sourcing and development engine allows us to identify promising science, deploy capital and teams of drug development experts, and provide stewardship to advance new medicines. By leveraging established expertise and repeatable functional models, we achieve vast efficiencies in execution speed and resource utilization.

To date, we have 14 novel therapeutics in development, and having closed a Series C financing round in October 2021 which raised $100 million, we plan to expand the number of programs. Further, we expect to initiate clinical trials for three programs in the next 18 months.

About the Cambrian Biomarkers Program:

The candidate will play a key role in a human clinical data-analytics program that will be deployed across Cambrian’s 15+ therapeutics under development. This innovative program will address regulatory challenges facing multi-disease preventative medicines by validating the causal linkages between age-related changes and age-related disease. Multiple academic groups and organizations have developed “aging clocks” that use individual biomarkers (e.g., DNA methylation patterns) to predict an individual’s likelihood of developing age-related disease. This program will apply advanced analytics to coalesce these distinct technologies into a single composite biomarker that can predict age-related multimorbidity risk: the likelihood of an individual developing any one of multiple age-related diseases. Thorough validation of such a biomarker could unlock a pathway to accelerated approval for healthspan therapeutics, making a larger number of these promising medicines available to patients faster.

Position Overview:

The Vice President, Preemptive Medicine will design clinical strategy for Cambrian’s pipeline assets and manage a team to develop novel analytic and biomarker capabilities in support of that strategy. This person will be supported by a team of highly engaged colleagues with significant entrepreneurial and scientific experience including operations, R&D, and data science experts. The successful candidate will bring vision, strategy and leadership to develop and execute on biomarker strategies to enable drug development candidates to move through clinical development. Keys for success will include devising scientifically sound biomarker strategies, effective implementation of assays into clinical trials, and communicating data and program impacts to key stakeholders and project teams.

Responsibilities:

• Build and maintain technical expertise on the latest developments in clinical and aging biomarkers
• Develop deep understanding of select technologies as they become relevant to Cambrian’s programs
• Collaboratively design target outcomes and experimental methodology to develop novel biomarkers
• Identify and support analysis of technical quality for potential datasets that will allow initial hypothesis testing of novel biomarkers
• Engage with potential partners to assess utility of data sets and technologies
• Provide clinical and translational advice to our early project teams as they assess novel targets and consider potential clinical indications
• Participate in preparation of regulatory documents and in face-to-face meetings with regulatory agencies
• Organize and present data at relevant internal and external meetings
• Collaborate with cross-functional personnel to drive biomarker and analytics programs

Qualifications:

• PhD, MD, or MD/PhD with 10+ years of experience (or equivalent) in a relevant scientific field (e.g. pathology, immunology, oncology, molecular biology, genetics), ideally with experience as a biomarker lead in pharma/biotech industry
• Demonstrated biopharmaceutical industry experience planning and executing clinical programs, and creating submissions for health authority approvals
• Excellent communication & organizational skills with a strong business acumen; able to convey complex scientific and business issues to devise, reach agreement on, and implement solutions
• Proven ability to collaborate, lead, influence, and motivate others
• Strong working knowledge of biomarkers and biostatistical principles in clinical trial design

Cambrian Offers:

• Opportunities to shape new and exciting science and build teams that bring novel therapeutics to patients in need
• Exposure to the biotech company life cycle and industry
• A dynamic, mission-driven, and entrepreneurial company culture
• Access to our network of international decision-makers and investors
• Competitive salary + equity
• 12 company holidays and an unlimited vacation policy
• Multiple health, vision, and dental insurance plans to choose from, including no-monthly-premium options supporting individuals and families

Cambrian Biopharma is proud to be an Equal Employment Opportunity and affirmative action employer. We celebrate diversity and do not discriminate based on race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state, or local laws.

This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation, and training