Casma Therapeutics is developing a novel targeted protein degradation approach based on the autophagy-lysosome system in order to open new target areas for drug discovery and development that will profoundly impact the lives of patients. Autophagy is a conserved cellular process that contributes to overall cellular homeostasis. In comparison to the proteasome, the autophagy machinery targets larger and more complex disease targets-such as organelles, protein aggregates and large signaling complexes and directs them to the lysosome for elimination. By selectively degrading disease targets by autophagy, Casma expects to be able to arrest or reverse the progression of disease in multiple oncology, inflammation, neurodegeneration, and metabolic disorders. Casma was launched in 2018 by Third Rock Ventures. In total, Casma has raised $154.5M in Series A, B and C financing.
The highly motivated Senior Associate Scientist works at the intersection of our Biology and Drug Discovery teams. The individual plays a critical role in developing Casma’s novel degrader platform by building a suite of assays to examine cellular engagement and degradation across targets. The ideal candidate is a team player possessing strong core competencies in cell biology, molecular biology and assay development, shares our excitement about the science, contributes to our culture, and honors our commitment to patients.
Requirements + Qualifications
Additional preferred skills
Company Values + Culture
Courage to listen, learn, lead, Awesome science, Strength through collaboration, Medical breakthroughs for patients, Always do the right thing
We are sustaining a creative scientific culture where we recognize and reward our “Casmaniacs” for exemplifying our Core Values, and we accelerate our professional growth through coaching, development, and frequent feedback. Our plan of nurturing the fiercest, most talented and diverse Casmaniacs has come to fruition. Consider joining us.
Casmaniacs are provided competitive salaries, stock options, bonus eligibility, and excellent benefits including health, dental and vision insurance, life insurance, long-term disability, 401(k) match, flexible vacation, generous parental leave, commuter reimbursement, professional development, philanthropic opportunities, and most importantly a sense of community and belonging.
Equal Employment Opportunity
Casma provides equal employment opportunities to all employees and applicants for employment without regard to race, color, national origin, religion, sexual orientation, gender, gender identity or expression, age, veteran status, disability, pregnancy or conditions related to pregnancy, or genetics.