Scientist / Senior Associate Scientist, Upstream Process Development of Biologic

Elevian is looking for an enthusiastic, self-motivated, detail-oriented Scientist or Senior Associate Scientist with upstream process development experience. The successful candidate will play an important role in conducting development and optimization of bench-scale cellular bioproduction process to support in-house research scale production of recombinant protein and antibody therapeutics and to ensure seamless technology transfer to a contract development and manufacturing organizations for GLP/GMP manufacturing. The successful candidate will be a key member of a fast-paced R&D team, collaborating collegially and cross-functionally to help Elevian develop its first and next generation biotherapeutics for aging-related diseases, initially focusing on stroke-recovery.

Primary Responsibilities:

• Establish in-house upstream bioprocessing capabilities for mammalian cell culture using CHO cell lines in bench scale bioreactors from cell-thaw through harvest.
• Design and execute upstream process development experiments to characterize, optimize upstream processes in shake flasks and bench scale bioreactors, ultimately to support development of robust and scalable bioreactor processes.
• Perform analytical and biochemical methods to monitor cell growth, metabolic profiles, and productivity of cultures.
• Serve as a technical liason between Elevian and external partners for seamless technology transfer to a manufacturing setting by collaborating with offsite colleagues.
• Document and effectively communicate results through oral presentation and written reports in a timely manner.
• Develop SOPs and batch records for both internal and outsourced manufacturing activities.
• Provide guidance and technical support to colleagues and peers.
• Contribute to multiple projects within the Elevian product development pipeline.

Education, Behavioral Competencies, Skills, and Qualifications

• PhD/MS in Chemical/Biochemical Engineering, Biotechnology or related discipline required
• Must have 2 - 5 years of upstream process development experience using small and medium scale bioreactors in standard or single use modalities (e.g. disposable wave or other S.U.Bs)
• Experience with mammalian expression platforms (HEK293Expi and/or CHO in suspension culture) will be required.
• Experience with protein quantification using ELISA and BLI (Octet) needed.
• Knowledge of cell banking, use of design of experiments (DOE) and statistical analyses for bioprocess study design and evaluation will be valued.
• Working knowledge of GxPs will be valued.
• Ability to multi-task and work cooperatively with a diverse group of colleagues will be required.

Please reach out to us at careers@elevian.com to share your resume and learn more. Please indicate the position you wish to be considered for in the subject line.