Research Associate/Senior Research Associate, Proteomics

Who we are:

Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives.

Position description:

Calico is seeking an experienced Research Associate/Senior Research Associate to join the mass spectrometry proteomics group. To succeed, you will need to be an enthusiastic team player, detail-oriented, organized and comfortable working on complex problems. We are looking for someone with detailed knowledge of proteomics and biochemistry techniques, and with demonstrated hands-on application. This is a hands-on bench position, focused on sample preparation, method development, instrument maintenance, troubleshooting and data analysis. The successful candidate will work with a large number of samples for collaborative projects, optimize and develop methods, as well as be responsible for smaller research projects. The Proteomics group collaborates with multiple labs within Calico, and as such is involved in many areas of research from oncology to immunology, as well as technology and assay development.

Responsibilities: 

• Prepare samples from tissues, cells, and biofluids
• Optimize and develop new sample preparation methods
• Maintain and troubleshoot instruments including HPLCs, mass spectrometers and other bioanalytical equipment
• Analyze data to share with collaborators

Position requirements:

• BS with 0-5 years of research experience
• Experience in sample preparation for proteomics (e.g. isobaric labels)
• Experience in method development for HPLC and/or mass spectrometers
• Experience in maintaining and troubleshooting HPLCs and mass spectrometers
• Detail-oriented and organized
• Strong teamwork and communication skills
• Self-motivated with a “can-do” attitude is required for success
• Flexible, able to respond quickly to shifting priorities and able to multitask
• Demonstrated ability to design, execute and draw conclusions from scientific projects

Nice to have:

• Experience maintaining Thermo mass spectrometers (e.g. Eclipse/Lumos) and HPLC
• Experience in automation and liquid handling platforms
• Experience in affinity/immunoprecipitation of proteins and post translational modification
• Experience in native fractionation FPLC/HPLC
• Experience in proteomic data analysis

Calico requires all new hires to be fully vaccinated for COVID-19 prior to the first date of employment.  As required by applicable law, Calico will consider requests for Reasonable Accommodations.