Scientist, Genetic Perturbations

Who we are:

Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives.  Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science, and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.

Position description:

Calico is seeking a motivated scientist to join and collaborate with researchers on projects that involve gene delivery in vivo.  Research will be conducted in close collaboration with multidisciplinary scientists at Calico. We provide a stimulating and collaborative working environment focused on fundamental discovery research and a commitment to translate scientific advances to realize their therapeutic potential.

Responsibilities:

This position will be responsible for conducting animal and cell culture work, developing, or applying methods to manipulate genes/pathways in mice, analyzing and presenting data. A successful candidate will have good communication skills, sufficient understanding of the in vivo system, be passionate about making scientific discoveries, and advancing technologies/methods related to gene delivery in vivo (e.g., AAVs, LNPs, etc.).

Position requirement:

• Ph.D. in biological sciences or related areas
• Experience in working with AAV or LNPs
• Experience with in vivo techniques, including mouse handling, necropsy, dosing
• Experience in cell culture, molecular biology and cell biology techniques
• Ability to conduct research, analyze data and present findings
• Demonstrate productivity through publications or patents
• Must be willing to work onsite at least four days per week

Nice to have:

• Knowledge of LNP formulation and particle characterization
• Demonstrate expertise in multi-disciplinary, multi-organ systems, including lung, liver, spleen etc.
• Experience in histology, imaging, FACS etc.
• Experience in performing survival procedures (e.g., surgeries, imaging) in mice

The estimated base salary range for this role is $127,000 - $135,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.