Group Leader, Functional Genomics

Company info

NewLimit is a biotechnology company working to radically extend human healthspan. We’re developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale.

Description

NewLimit is seeking an functional genomics scientist with leadership experience to lead our Functional Genomics team. Our Functional Genomics team is focused on developing and deploying pooled screening methods to discover partial reprogramming targets. Our team has already developed methods sufficient to perform reprogramming screens at >100X the scale of prior art.

Your role will focus on improving the fidelity and scale of these methods, deploying them to new cell types, and reducing the associated costs and turn-around times to optimize the number of discoveries we make per day, per dollar.

In your role as a Group Leader, you will:

• Lead & recruit a team of Scientists and Research Associates
• Develop new functional genomics technology & execute production scale reprogramming screens in collaboration with our Single Cell Technology & Predictive Modeling teams
• Contribute to laboratory implementations and training at the bench — Everyone Executes at NewLimit
• Develop methods for the construction, delivery, and control of partial reprogramming payloads in primary mammalian cells of diverse cell types
• Contribute to company-wide decision making on indication selection, program prioritization, and resource allocation

Requirements

• Ph.D. in molecular biology, cell biology, or a related field or equivalent industry experience (5+ years)
• Experience leading a cross-functional team and managing direct reports
• Experience with functional genomics approaches for arrayed or pooled screening (e.g. one of: CRISPR-Cas pooled fitness screens, gene expression perturbation profiling, CROP/Perturb-seq, or similar methods)
• Experience with in vitro and in vivo transgenic delivery methods for mammalian cells (at least one of: lentivirus, AAV, AdV, transposition systems, CRISPR-Cas targeted editing, lipid nanoparticles, or similar)

Nice to have

• Therapeutics discovery & development experience
• Experience with epigenetic reprogramming methods using transcription factors for cell fate engineering or CRISPR-Cas tools for targeted epigenetic editing
• Experience working with primary cells and tissue samples
• Experience with single cell genomics methods
• Programming ability in one of: Python, R, Rust

Benefits

NewLimit offers generous benefits to ensure our team can focus on our mission:

• Health, dental, and vision insurance
• 401(k) with company match
• Paid parental leave
• Industry-leading paid time off (PTO) — 20 days/year for all employees + holidays
• Meals and snacks on-site

Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Learn more at: https://www.newlimit.com/careers   *This compensation and benefits information is based on Company's good faith estimate as of the date of publication and may be modified in the future.