Principal Research Scientist, Dug Discovery

Yuva Biosciences, Inc. is seeking an exceptional drug discovery scientist to drive the development and incorporation of
new approaches to identify candidate agents to enhance mitochondrial function. Along with an associate scientist, the
team will be responsible for designing, developing, and executing in vitro and in vivo assays to support progression,
optimization, and mechanism of action of mitochondrial therapeutics.

The ideal candidate will possess leadership abilities to direct and manage a lab and coordinate activities across multiple
drug discovery initiatives and platforms. Prior experience in the mitochondrial biology and genetics field is a plus. The
candidate must work well in a growing organization, make clear decisions in a fast-paced drug discovery environment
and be highly proficient in both verbal and written communication to audiences with diverse scientific, professional and
drug discovery backgrounds. Independently performs scientific experiments with a predefined goal, including developing
new strategies.

Qualifications
• Ph.D. in Pharmacology, Molecular Biology, Cell Biology or related field with minimum 2 to 3 years post-doctoral
experience or industry experience
• Experience and demonstrated excellence in early phase drug discovery, target identification, and validation and
project team leadership.
• Strong strategic scientific and technical leadership in the design, execution, analysis, and interpretation of a broad
range of mitochondrial assays to drive identification of compounds leading to progression and elucidation of the
mechanism of action.
• Experience in preparing clear technical reports, publications, and oral presentations: independently communicating
results; presenting clearly and effectively and defending own work at internal & external meetings; delivering updates
to management in the context of overall project goals. Keeps abreast of relevant literature relevant to research
projects and competitive landscape.
• Understanding of classical pharmacological principles and drug discovery process, in order to support an
assessment of potency, efficacy and contribute to predictions of human efficacy
• Ability to critically analyze and interpret data and effectively document and communicate results
• Has a demonstrated ability to apply a variety of state-of-the-art biochemical and genetic methods related to cell
proliferation, apoptosis, cytotoxicity, and molecular pathways related to therapeutic agents.
• Has solid hands-on experience in handling mice and basic cell culture / genetic manipulation techniques as well as
molecular and cell biology approaches.
• Strong working knowledge of computer software including Excel and PowerPoint and additional scientific analysis
software including Prizm GraphPad, SpotFire, XL-Fit or comparable scientific data applications.

Additional/Preferred Qualifications

• Experience in leading a group in a pharmaceutical or biotechnology setting.
• Mitochondrial assay development expertise, including biochemical and cell-based assays
• Experience in development of innovative translational in vitro and/or in vivo models that predict human efficacy