Postdoctoral Fellow, Tumor Cell Biology - Firestone Lab

Calico Life Sciences is recruiting a Postdoctoral Fellow to join our growing world-class oncology group. We seek a highly motivated individual with a background in cellular or molecular biology who is interested in pursuing basic research related to developing a more comprehensive understanding of the interaction between cellular nucleic acid species and their interactions with various innate immune triggering receptors, as well as the context-specific consequences of these interactions on cellular phenotype.

We anticipate the successful candidate will work closely with other Calico scientists to generate and execute a comprehensive experimental plan for investigating the above questions utilizing cell line engineering, cutting edge epigenomics techniques, and computational modeling.  Results from these studies may help to guide ongoing or new therapeutic programs in which the candidate will have the opportunity to participate.

Responsibilities: 

• Generate mammalian cell lines with multiple gene editing events
• Perform and develop CUT&RUN like and other epigenomics assays
• Drive or work closely with others on NGS data analysis

Position requirements:

• PhD in cellular or molecular biology or related field
• Experience with mammalian tissue culture and cell line engineering
• Ability to work with NGS data a strong plus

Calico Postdoctoral Fellowship Program:

Calico’s Postdoctoral Fellowship Program pairs recent PhD graduates with internal expertise to conduct fundamental and innovative research and investigate meaningful scientific questions aligned with our mission to understand the biology of human aging and develop interventions for age-related diseases. Postdoctoral Fellows at Calico receive mentorship and support to develop independent research programs to enable the next stage of their careers. In addition to direct mentorship from their host laboratories, Postdoctoral Fellows benefit from collaboration with diverse scientists across Calico’s Research and Technology groups and are encouraged and supported to communicate their findings through high-impact, peer-reviewed scientific journals and conferences.

Program Features:

• Fully integrated into Calico’s labs and community, Postdoctoral Fellows pursue new research directions with devoted resources for innovative and potentially high-risk research and bring new personalities, ideas, technology and perspectives to Calico.
• Calico’s program is a fixed-term educational assignment for individuals who have recently completed their PhD degrees, have had a meaningful first author paper accepted for publication, and have made important contributions to science in their area.

• While postdocs will focus on their own project(s), mutually agreed to in principle and prior to making the decision to join the mentor’s lab, the expectation is that they all contribute to furthering our understanding of aging and age-related diseases.
• Postdoc assignments are up to four years in length. It is expected that the postdoc will receive regular feedback and guidance from their mentor in addition to participating in a more formal annual review process to discuss project progress, individual performance, and career coaching.
• Our postdoc projects are expected to yield work that can be submitted for publication in a timely fashion upon completion and are intended to train people to become independent investigators in an academic or industry setting upon successful completion of the assignment.
• Calico postdocs join a community of other Postdoctoral Fellows who regularly engage with members of Calico’s scientific community, including senior leadership, through a variety of professional and career development opportunities.