Postdoctoral Fellow, Proteomics

Calico is seeking a postdoctoral candidate to join the mass spectrometry proteomics group. To succeed, you will need to be an enthusiastic team player, detail-oriented, organized and comfortable working on complex problems. The work will involve developing and applying proteome profiling methods and protein interaction profiling technologies such as CETSA, PISA and native fractionation techniques. The work will also involve profiling post translational modifications (PTMs). You will work with many different sample types and body fluids from aging-related disease samples, optimize and develop sample preparation and mass spectrometry methods. You will have access to state of the art LC-MS/MS platforms as well as high throughput automated liquid handlers. This post-doctoral position is ideal for someone who excels at wet lab but also has some computational biology training.

Responsibilities: 

• Develop and lead proteomics projects such as proteome profiling methods for studying proteome profiling in aging and aging related diseases. In particular, this will include proteome profiling of protein complexes, protein interactions and PTMs
• Develop and optimize proteomics protocols and apply to a wide variety of samples such as aging and aging-related disease samples
• Collaborate with scientists both in the proteomics group and outside to apply novel and optimized proteomics workflows to investigate aging and aging related diseases

Position requirements:

• PhD, in proteomics, biochemistry, chemistry, biology or related field
• Experience in sample preparation and method development for proteomics
• Experience in maintaining and troubleshooting HPLCs and mass spectrometers
• Experience in PTMs

Nice to haves:

• Experience in R/Matlab/Python or other programing language
• Experience in CETSA/PISA analysis
• Experience in native fractionation techniques
• Experience in microbiome analysis

Calico Postdoctoral Fellowship Program:

Calico’s Postdoctoral Fellowship Program pairs recent PhD graduates with internal expertise to conduct fundamental and innovative research and investigate meaningful scientific questions aligned with our mission to understand the biology of human aging and develop interventions for age-related diseases. Postdoctoral Fellows at Calico receive mentorship and support to develop independent research programs to enable the next stage of their careers. In addition to direct mentorship from their host laboratories, Postdoctoral Fellows benefit from collaboration with diverse scientists across Calico’s Research and Technology groups and are encouraged and supported to communicate their findings through high-impact, peer-reviewed scientific journals and conferences.

Program Features:

• Fully integrated into Calico’s labs and community, Postdoctoral Fellows pursue new research directions with devoted resources for innovative and potentially high-risk research and bring new personalities, ideas, technology and perspectives to Calico.

• Calico’s program is a fixed-term educational assignment for individuals who have recently completed their PhD degrees, have had a meaningful first author paper accepted for publication, and have made important contributions to science in their area.
• While postdocs will focus on their own project(s), mutually agreed to in principle and prior to making the decision to join the mentor’s lab, the expectation is that they all contribute to furthering our understanding of aging and age-related diseases.
• Postdoc assignments are up to four years in length. It is expected that the postdoc will receive regular feedback and guidance from their mentor in addition to participating in a more formal annual review process to discuss project progress, individual performance, and career coaching.
• Our postdoc projects are expected to yield work that can be submitted for publication in a timely fashion upon completion and are intended to train people to become independent investigators in an academic or industry setting upon successful completion of the assignment.
• Calico postdocs join a community of other Postdoctoral Fellows who regularly engage with members of Calico’s scientific community, including senior leadership, through a variety of professional and career development opportunities.