Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives.
Calico is seeking a clinical biostatistician with extensive experience in First-in-Human (FIH), Proof-of-Concept and non-traditional early phase studies in bringing novel therapeutics to the clinic, as well as experience in design and analysis of preclinical studies and large clinical data sets. The successful candidate will join a small and growing drug development organization responsible for advancing exciting drug candidates into clinical trials to treat diseases with high unmet medical need. The objective is to create an agile team to navigate new terrain in the approach to the early stages of drug development and would involve participation in cross-functional team meetings providing statistical support to early stage development programs. The successful candidate is also expected to consult to teams in preclinical stages of development on study design and analytic methods, as well as consult to teams analyzing large clinical data sets.
Calico’s approach to drug development is supported by some of the world’s most talented life scientists. This position offers a unique opportunity to build a creative, effective and efficient approach to drug development at the leading edge of evolution in scientific knowledge, and the opportunity to collaborate with our innovative Computational group, including computational biologists, data scientists, machine learning and data platform engineers.
Design and author statistical analysis plans for clinical protocols
Analyze nonclinical and/or clinical datasets and present results in written form and verbally
Participate in authorship of Clinical Study Reports
Work collaboratively with cross-functional teams to develop study designs and endpoints, including nonclinical studies and/or Phase 0-Phase 2 clinical studies across multiple therapeutic areas
Ph.D. in statistics or biostatistics
A minimum of 5 years of drug development industry experience (Biotechnology or Pharmaceutical) in clinical biostatistics supporting early drug development (FIH through to proof-of-concept) and/or nonclinical studies that have relevance for clinical translation
Expertise in nonclinical and/or clinical statistical trial design
Ability to lead analysis, data visualization and reporting of nonclinical and/or clinical trial results
Ability to review experimental and/or large data sets for potential biomarker development or nonclinical/clinical trial design
Software capability in trial design and data analysis such as R Studio and SAS
Detail-oriented mindset including experience in teamwork and productive collaboration on cross-functional complex projects
Self-motivated with strong track record of driving results
Demonstrated ability to work largely independently, with a moderate amount of direction from functional management
Excellent verbal and written communication skills
Management experienced is desired, but not required
Must be willing to work onsite at least three days per week
Calico requires all new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Calico will consider requests for Reasonable Accommodations.