Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science, and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.
Calico is seeking a scientist who is excited to be part of a research team focused on translational research in integrated physiology and oncology. The role requires an experienced in vivo scientist with a strong background in biology, including expertise with animal disease models pertaining to tumor biology and in vivo pharmacology. This individual contributor role will collaborate with multiple Oncology research groups to plan, execute and analyze preclinical mouse studies. A wide range of animal models including syngeneic, GEM, CDX, PDX and humanized tumor models are used. As a highly organized, self-motivated individual with a strong lab/practical background you will stay up to date with relevant techniques and have a genuine passion for this field of research. The position requires strong interest in experimental work and ability to work in a fast-paced work environment.
Require high level of independence in performing all aspects of in vivo experiments, but also function as an effective team player and enthusiastic collaborator with other members of the cross-functional team.
Perform standard mouse in vivo work (including tumor inoculation and growth monitoring, body weight monitoring, i.p, i.v., s.c., i.t. injection skills) across diverse in vivo mouse models (including syngeneic models, xenograft models, humanized mouse models).
Design, execute and interpret preclinical experiments focused on oncology and immunology translational programs.
Perform ex vivo PD assessment assays (basic biochemical and immunological methods including cell culture, multi-color flow cytometry, ELISA/multiplex assays.
Excellent time management skills and manage experiments in several projects concurrently.
Maintain accurate experimental records and generate scientific data reports for project team discussion and future publications.
Comply with Calico IACUC regulations, animal use protocols, experimental study design protocols and standard operating procedures in place for conducting in vivo studies.
Must be willing to work onsite at least four days per week.
Recent PhD with relevant lab experience or BS/MS with minimum 10+ years of industry experience.
Proven track record of hands-on experience with the creation and development of in vivo mouse tumor models and their application in evaluating anti-cancer therapies.
Experience in developing cancer immunotherapeutics is highly desired.
The estimated base salary range for this role is $127,000 - $147,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.
Calico requires all new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Calico will consider requests for Reasonable Accommodations.