Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.
We are seeking a Head of Human Biology to lead Calico’s efforts to use large scale human cohorts to systematically understand the biology of aging and disease pathogenesis, in order to discover and validate novel therapeutic targets.
The Head of Human Biology will be a key member of Calico’s Research leadership team. Candidates will have demonstrated interest in exploring large human cohorts with a strong record of scientific achievement. This person will be expected to have broad impact across the organization, leading both scientifically and strategically and playing a key role in the use of human data to advance Calico’s long term research goals. This individual will possess strong leadership skills and a track record of successful discovery research and interest in translating discoveries into novel interventions in age-related diseases. The successful individual will join an ecosystem of collaborative, enthusiastic, rigorous, interdisciplinary scientists who are employing state-of-the-art technologies and computational approaches to elucidate the fundamental mechanisms of aging and their impact on age-related diseases.
Direct a group of Principal Investigators and oversee their research programs
Direct an independent research effort aimed at gaining valuable insights from human data
Provide scientific direction, including clinical insights, for a broad range of translational projects
Recruit top talent with human data as a key focus
Join Calico’s Scientific Review Committee
Contribute overall to Calico’s ambitious research efforts to understand the fundamental biology of aging and discover mechanisms that contribute to human longevity
MD/PhD preferred, with PhD in computational biology, genetics, epidemiology, physiology, molecular/cellular biology, systems biology; relevant practical experience
Rising/proven leader in academia or industry with 10+ years of professional experience
Strong record of creative scientific achievement with a track record of impactful publications exploring human cohort data
Recognized for novel mechanistic insights and important discoveries
Experience managing other scientists
Ability to integrate across many areas of biology with ease
Excellent communication skills
A passion to translate cutting-edge science into therapeutic opportunities
Must be willing to work onsite at least three days per week
Nice To Have:
Experience with GWAS and post-GWAS methods such as Mendelian randomization and variant interpretation
Experience with association studies using high content phenotypes such as medical images
Experience with experimental medicine or clinical drug development
Familiarly with basic machine learning concepts
‘Wet lab’ experience
Well-developed relationships with the academic scientific community
The estimated base salary range for this role is $314,000 - $400,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.