Genomic instability, Telomere attrition, Epigenetic alterations, Loss of proteostasis, De-regulated nutrient sensing, Mitochondrial dysfunction, Cellular senescence, Stem cell exhaustion, Altered intercellular communication
Aging has been called “the emperor of all maladies.” Turn Bio’s goal is to address multiple aging-related indications using a single powerful reprogramming therapy that turns old cells young again, aiding in the rejuvenation of an aged human body.
In 2013, a paper in Cell (The hallmarks of aging, López-Otin et al.,) proposed nine key “Hallmarks of Aging” that are causes of the general phenotype we refer to as “aging.” Our team recognized that it would be necessary to “turn back the clock” on each of these hallmarks and so set out to develop the technology to do just that. The task was achieved by a using a proprietary cocktail of transiently-administered rejuvenation factors that have now been shown to reverse eight of the nine hallmarks.
Join us as we embark on the task to "turn back time."